Catalytic Enantioselective Alkylation and Arylation of Aldehydes by Using Grignard Reagents
نویسندگان
چکیده
منابع مشابه
Enantioselective Addition of Grignard Reagents to Aldehydes
The addition of Grignard reagents to aldehydes in the presence of chiral aminoalcohols shows a moderate enantioselectivity. The study carried out with a series of ligands allows the correlation between the structural characteristics and their reactivity. Introduction The use of chiral aminoalcohol to lead asymmetrically nucleophilic additions of organometallics to carbonyl compounds is a field ...
متن کاملCatalytic enantioselective addition of Grignard reagents to aromatic silyl ketimines
α-Chiral amines are of significant importance in medicinal chemistry, asymmetric synthesis and material science, but methods for their efficient synthesis are scarce. In particular, the synthesis of α-chiral amines with the challenging tetrasubstituted carbon stereocentre is a long-standing problem and catalytic asymmetric additions of organometallic reagents to ketimines that would give direct...
متن کاملCatalytic alkylation of aryl Grignard reagents by iron(III) amine-bis(phenolate) complexes.
Reaction of n-propylamino-N,N-bis(2-methylene-4-tert-butyl-6-methylphenol), H(2)L1, n-propylamino-N,N-bis(2-methylene-4,6-di-tert-butylphenol), H(2)L2, and benzylamino-N,N-bis(2-methylene-4-tert-butyl-6-methylphenol), H(2)L3, with anhydrous ferric chloride in the presence of base yields the products, [FeL1(μ-Cl)](2) (1), [FeL2(μ-Cl)](2) (2) and [FeL3(μ-Cl)](2) (3). In the solid state, these com...
متن کاملDirect, enantioselective α-alkylation of aldehydes using simple olefins.
Although the α-alkylation of ketones has already been established, the analogous reaction using aldehyde substrates has proven surprisingly elusive. Despite the structural similarities between the two classes of compounds, the sensitivity and unique reactivity of the aldehyde functionality has typically required activated substrates or specialized additives. Here, we show that the synergistic m...
متن کاملAsymmetric amplification in the catalytic enantioselective 1,2-addition of Grignard reagents to enones.
Large asymmetric amplification originating from solubility differences between the enantiopure and the racemic catalyst is observed in the addition of Grignard reagents to enones. This behaviour is not reaction or catalyst specific and is observed for metal complexes of a variety of chiral diphosphine ligands, extensively used in asymmetric catalysis.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 2010
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.20090232